The name Alexande is derived from the Greek name Alexandros, which is a compound of the words alexo, meaning "to defend," and andros, meaning "man." The name can be traced back to ancient Greece, where it was a popular name among the ruling class and members of the military.

One of the most famous bearers of the name was Alexander the Great, the Macedonian king who lived from 356 to 323 BC. He was one of the most successful military commanders in history, conquering much of the known world at the time, including parts of Europe, Asia, and Africa. His achievements and legacy have made the name Alexande synonymous with leadership, bravery, and conquest.

In the Bible, there is a character named Alexander, who was a member of the high priestly family and is mentioned in the book of 1 Maccabees. This reference suggests that the name was also in use among the ancient Jewish community.

During the Middle Ages, the name Alexande became popular across Europe, particularly in regions with strong cultural ties to Ancient Greece and Rome. Notable figures from this period include Alexander Nevsky (1220-1263), a Prince of Novgorod and Grand Prince of Vladimir, who led the Russian forces against the Swedes and the Teutonic Knights.

In the Renaissance era, the name continued to be associated with scholars, artists, and intellectuals. One of the most famous individuals with this name was Alessandro di Mariano di Vanni Filipepi, better known as Sandro Botticelli (1445-1510), the Italian painter of the Early Renaissance period.

Other notable figures with the name Alexande include Alexander Hamilton (1755-1804), one of the Founding Fathers of the United States and the first Secretary of the Treasury; Alexander Graham Bell (1847-1922), the Scottish-born inventor of the telephone; and Alexander Fleming (1881-1955), the Scottish biologist who discovered penicillin.