The name Alexis originated from the Greek language and culture. It is derived from the Greek word "alexo", meaning "to defend" or "to help". The name first appeared in ancient Greece around the 5th century BC.

In ancient Greek mythology, Alexis was the name of a young man who was loved by the poet Virgil. The name is also associated with the Greek goddess Alexiara, who was known as the protector against illness and disease.

One of the earliest recorded examples of the name Alexis is found in the writings of the ancient Greek philosopher Plato. In his work "Symposium", Plato mentions a character named Alexis who was a young man of great beauty.

Another early historical figure with the name Alexis was Alexis Comnenus, who was a Byzantine prince and military leader in the 11th century AD. He played a significant role in the defense of the Byzantine Empire against the Seljuk Turks.

During the Renaissance period, the name Alexis gained popularity in Europe. One notable figure was Alexis Piemontese, an Italian philosopher and theologian who lived in the 15th century. He wrote several works on moral philosophy and theology.

In the 17th century, Alexis I, also known as Alexis Mikhailovich, was the Tsar of Russia from 1645 to 1676. He was known for his efforts to modernize and westernize Russia, and for his involvement in the Russo-Polish War.

Another famous historical figure with the name Alexis was Alexis de Tocqueville, a French political thinker and historian who lived in the 19th century. He is best known for his work "Democracy in America", which analyzed the American political system and society.