The given name Anastacio has its roots in the Greek language, originating from the word "anastasis" which means "resurrection" or "rise." This name's origins can be traced back to the early Christian era when it was initially used within the Byzantine Empire.

One of the earliest recorded instances of the name Anastacio appears in the writings of the late antique historian Procopius of Caesarea, who lived in the 6th century AD. His works mention an individual named Anastacio who served as a high-ranking military officer during the reign of the Byzantine Emperor Justinian I.

The name Anastacio also holds significance in the Eastern Orthodox Church, as it was borne by several notable saints and martyrs. One of the most revered figures was Saint Anastacio the Persian, a 7th-century martyr who was executed for his Christian faith during the Sassanid period in Persia (modern-day Iran).

Throughout history, several notable individuals have been named Anastacio. One of the earliest examples is Anastacio Pantaleón, a 12th-century Spanish prelate who served as the Archbishop of Toledo from 1209 to 1218. Another prominent figure was Anastacio Aquino (1756-1833), a Filipino Catholic priest and one of the leading figures in the Philippine Revolution against Spanish colonial rule.

In the realm of literature, Anastacio Gisbert (1802-1875) was a Spanish playwright and poet who made significant contributions to the development of Spanish Romantic theater. Additionally, Anastacio Somoza García (1896-1956) was a Nicaraguan political figure who served as the President of Nicaragua from 1937 to 1947 and again from 1950 to 1956.

Anastacio Bucaram (1952-present) is a contemporary Ecuadorian politician who served as the President of Ecuador from 1996 to 1997 before being ousted by the National Congress amid political turmoil and protests.

While the name Anastacio has its origins in the Greek language and early Christian history, it has been adopted and utilized across various cultures and regions over the centuries, with notable individuals bearing this name throughout the world.