The name Antwain is of English origin, derived from the Old English words "aentu" meaning "one" and "wine" meaning "friend". It was initially used as a masculine given name in the Middle Ages, around the 12th century.

In the early days, the name was commonly spelled as "Antwine" or "Antwyne". This variation in spelling was common during that time due to the lack of standardized spellings for names and words. The name was primarily used by English families, particularly those residing in the southern regions of England.

One of the earliest recorded instances of the name Antwain can be found in the Domesday Book, a manuscript record of landholdings and estates in England compiled in 1086 under the orders of William the Conqueror. This document mentions an individual named "Antwine de Boulogne", who was a landowner in the county of Somerset.

Throughout the Middle Ages, the name Antwain remained relatively uncommon, but it was occasionally used by noble families and members of the gentry. One notable historical figure who bore this name was Antwain de Vere, a 13th-century English nobleman who served as a knight and held lands in Essex.

In the 16th century, the name gained some popularity among Puritan families in England, as they often favored names with Biblical or religious connotations. During this time, the spelling "Antwain" became more prevalent, although variations like "Antwyn" and "Antwayne" were still used.

One of the most famous historical figures with the name Antwain was Antwain Pearson, an English Puritan minister and theologian who lived from 1628 to 1688. He was an influential figure in the religious landscape of his time and authored several notable works on theology and Christian doctrine.

In the 18th and 19th centuries, the name Antwain experienced a decline in popularity, but it was still used occasionally by English families. One noteworthy individual was Antwain Fielding, a British explorer and naturalist who lived from 1787 to 1855. He is known for his expeditions to various parts of Africa and his contributions to the field of natural history.

Another prominent figure with the name Antwain was Antwain Davenport, an English artist and painter who lived from 1832 to 1911. He was renowned for his landscapes and portraits, and his works are still admired and displayed in various art galleries and museums around the world.