The name Apolonio has its origins in Ancient Greek, derived from the name Apollonios, which was a masculine form of the name Apollo. Apollo was the Greek god of music, poetry, art, oracles, archery, plague, medicine, sun, and light. The name Apollonios was widely used in ancient Greece and the broader Hellenic world.

Apollonios was the name of several notable historical figures in antiquity. One of the most famous was Apollonius of Rhodes, a 3rd-century BC scholar and poet best known for his epic poem, the Argonautica, which recounted the voyage of Jason and the Argonauts in their quest for the Golden Fleece. Another Apollonius of note was Apollonius of Tyana, a 1st-century AD Pythagorean philosopher and teacher who gained a reputation as a miracle worker and was revered by many as a divine figure.

The name Apollonios underwent various spelling changes over time, eventually evolving into the form Apolonio in some regions. One of the earliest recorded instances of this spelling can be found in the work of the 13th-century Italian poet Dante Alighieri, who mentions a character named Apolonio in his famous work, the Divine Comedy.

Throughout history, several notable individuals have borne the name Apolonio. These include:

1. Apolonio of Tyre, a legendary figure from a medieval romance tale dating back to the 10th century.
2. Apolonio Mellado, a 16th-century Spanish painter and engraver known for his works depicting religious subjects.
3. Apolonio Lozano, a 17th-century Spanish jurist and author of legal treatises.
4. Apolonio de Toro, an 18th-century Spanish composer and organist active in Madrid.
5. Apolonio Muñoz, a 19th-century Venezuelan military leader and politician who served as President of Venezuela from 1847 to 1851.

While the name Apolonio has its roots in ancient Greek culture and mythology, it has been adopted and used in various forms across different regions and time periods, with notable bearers of the name appearing throughout history.