The name Arabella has its origins in Latin and ancient Roman culture. It is derived from the Latin word "orabilis" which means "admirable" or "appealing". The spelling "Arabella" first appeared in the Late Latin period around the 5th century AD.

In early medieval times, the name spread through continental Europe amid the influence of Latin on emerging European languages and cultures. Variations in spelling and pronunciation emerged, such as Arabelle in French and Arabella in Italian and Spanish. It continued to be used as a feminine given name throughout the Middle Ages.

One of the earliest recorded bearers of the name was Arabella Stuart, born in 1575. She was an English noblewoman and a claimant to the English and Scottish thrones after King James VI of Scotland became King James I of England in 1603. Her claim was passed over in favor of her cousin, which sparked the "Arabella Plot" by her supporters in an attempt to take the throne.

In literature, the name appears in William Shakespeare's play The Tempest from around 1610-1611. A ship named "Arabella" is referenced, which may have been inspired by the political events surrounding Arabella Stuart at the time.

Arabella Churchill (1648-1730) was an English playwright and mistress of King James II of England. She was influential in restoring the Stuart monarchy during the Glorious Revolution of 1688.

Arabella Huntington (1850-1924) was an American philanthropist and artist who founded several museums and arts institutions in the United States, including the Huntington Library, Art Museum, and Botanical Gardens in San Marino, California.

Arabella Weir (born 1957) is a British actress and author, best known for her roles in comedy series such as The Fast Show, Smack the Pony, and as Professor Sprout in the Harry Potter films.

Arabella Steinbacher (born 1981) is a German violinist who has performed with leading orchestras worldwide and has won many prestigious awards for her classical violin performances.