The name Bonifacia is derived from the Late Latin name Bonifatius, which is a combination of the Latin words "bonus" meaning good and "fatus" meaning destiny or fate. This name essentially means "good fortune" or "good fate." The name Bonifacia is the feminine form of the masculine name Bonifacius.

Bonifatius was originally a Roman name, likely first used in ancient Rome during the classical period. It later became a popular name among early Christians, with several notable figures bearing this name in the early centuries of Christianity.

One of the earliest known individuals with the name Bonifacia was Saint Bonifacia, a 3rd-century Roman martyr. She was born in Rome and suffered martyrdom during the persecution of Christians under the reign of Emperor Diocletian in the early 4th century.

Another notable Bonifacia was Bonifacia Rodríguez de Castro, a Spanish nun and mystic who lived in the 16th century (1551-1622). She was known for her visions and spiritual writings, and was beatified by the Catholic Church in 1917.

In the 17th century, Bonifacia Rodríguez de Velasco (1599-1684) was a Spanish noblewoman and philanthropist who dedicated her life and wealth to charitable works, particularly in the city of Toledo, Spain.

During the 18th century, Bonifacia Massó (1766-1829) was a Spanish painter and engraver known for her religious artworks and portraits. She was one of the few female artists of her time to gain recognition in Spain.

In the 19th century, Bonifacia Álvarez Cano (1824-1892) was a Venezuelan poet and educator who played a significant role in promoting education and literature in her home country.

While the name Bonifacia has its roots in ancient Rome and early Christianity, it has been used across various cultures and regions over the centuries, reflecting its enduring appeal and meaning.