The name Casandra originated from Ancient Greek, derived from the elements 'kassandra', meaning 'she who entangles men'. It likely emerged around the 8th century BC in the region of Ancient Greece. The name was borne by the mythological princess Cassandra, known for her gift of prophecy and her tragic fate of having her predictions ignored.

Cassandra was a prominent figure in Greek mythology, appearing in various ancient texts, including Homer's Iliad and Aeschylus' Agamemnon. She was the daughter of King Priam and Queen Hecuba of Troy. Despite being blessed with the ability to foretell the future, she was cursed by Apollo to never be believed.

One of the earliest recorded instances of the name dates back to the 5th century BC, when a Greek woman named Casandra was mentioned in the writings of the historian Herodotus. In ancient Rome, the name was adapted to the Latin form 'Cassandra'.

Throughout history, several notable individuals have borne the name Casandra or its variations. One of the most famous was Casandra Fedele (1465-1558), an Italian Renaissance scholar and poet, renowned for her erudition and contributions to the humanist movement.

Another prominent figure was Casandra Clemmer (1888-1965), an American actress and dancer who performed on Broadway and in vaudeville shows during the early 20th century.

Casandra Ventura (born 1986), known professionally as Cassie, is a contemporary American singer, model, and actress, known for her hit songs "Me & U" and "Long Way 2 Go".

In literature, Casandra Mortmain is the name of the protagonist in the novel "The Pursuit of Love" by Nancy Mitford, published in 1945.

Casandra Brené Brown (born 1965) is an American research professor, lecturer, and author, known for her groundbreaking work on vulnerability, courage, and shame.