The name Celestine originates from the Late Latin name Caelestinus, which is derived from the Latin word caelestis, meaning "heavenly" or "celestial." The name has its roots in ancient Roman culture and is believed to have been first used during the early centuries of the Christian era.

The earliest recorded use of the name Celestine can be traced back to the 5th century, when it was borne by Pope Celestine I, who reigned from 422 to 432 AD. He is remembered for his efforts in combating the Pelagian heresy and for his correspondence with St. Augustine.

Another notable figure named Celestine was Pope Celestine V, born Pietro Angelerio (c. 1215-1296). He was a hermit who was elected pope in 1294 but abdicated after just five months, becoming the last pope to resign until Pope Benedict XVI in 2013.

In the 12th century, Celestine III, born Giacinto Bobone (c. 1106-1198), served as Pope from 1191 to 1198. He was known for his efforts to launch the Third Crusade and for his conflicts with the Holy Roman Emperor Henry VI.

The name Celestine also has literary connections, appearing in the works of French playwright Molière. In his play "Le Malade Imaginaire" (The Imaginary Invalid), one of the characters is named Toinette Celestine.

Another noteworthy bearer of the name was Celestine Douais (1851-1929), a French Catholic priest and historian who wrote extensively on the history of the Catholic Church in England and Scotland during the Middle Ages.

Over the centuries, the name Celestine has been used across various cultures and regions, particularly in Catholic communities. Its connection to the heavens and celestial realm has imbued it with a sense of spirituality and divine inspiration.