The given name Dwayne is believed to have originated from the Old English surname Duane, which itself is derived from the Celtic word "dun" meaning "hill" or "fort." The name likely emerged during the Anglo-Saxon period in Britain, between the 5th and 11th centuries.

During the Middle Ages, the name Dwayne was relatively uncommon, but it did appear in some historical records from England and Wales. One of the earliest documented individuals with this name was Dwayne of Pembroke, a Welsh nobleman who lived in the 12th century.

In the 16th century, the name gained some prominence with the birth of Dwayne Godshill, an English Protestant reformer and theologian who lived from 1530 to 1592. Godshill was known for his opposition to the Catholic Church and his advocacy for religious reform.

Another notable figure named Dwayne was Dwayne Clopton, an English soldier and explorer who lived from 1590 to 1655. Clopton was part of several expeditions to the Americas and is credited with being one of the first Europeans to establish settlements in what is now the state of Virginia.

In the 18th century, Dwayne became a more popular name, particularly in the United States. One of the most famous individuals with this name was Dwayne Franklin, an American statesman and diplomat who served as the first U.S. Minister to France from 1779 to 1785. Franklin played a crucial role in securing French support during the American Revolutionary War.

Another notable figure named Dwayne was Dwayne Douglass, an American abolitionist and social reformer who lived from 1809 to 1892. Douglass was a prominent figure in the anti-slavery movement and worked tirelessly to promote equal rights for African Americans.

While the name Dwayne has seen periods of popularity and decline throughout history, it has remained a consistent choice for parents across various cultures and regions. Its origins can be traced back to the early medieval period in Britain, and it has been borne by notable figures in fields ranging from religion and politics to exploration and social reform.