The given name Epifanio originated from the Greek language and culture. It can be traced back to the ancient Greek word "epiphanēs," which means "manifest" or "illustrious." This name was given to individuals who were considered to be manifestations of divine grace or who possessed exceptional qualities.

In the early Christian era, the name Epifanio gained significance due to its association with the Epiphany, a religious feast day celebrating the manifestation of Christ's divinity. The name was often bestowed upon children born around the time of the Epiphany celebration.

One of the earliest recorded uses of the name Epifanio can be found in the hagiography (writings about saints) of the 4th century. Saint Epiphanius of Salamis, a prominent church father and bishop, lived from around 310 to 403 AD. He played a crucial role in combating various heresies and is venerated in the Eastern Orthodox and Catholic churches.

During the Middle Ages, the name Epifanio continued to be used, particularly in regions with strong cultural ties to the Byzantine Empire and the Eastern Orthodox tradition. Notable individuals bearing this name include Epifanio de' Monici, an Italian prelate and diplomat who lived from 1437 to 1503.

In the Renaissance period, the name Epifanio was revived and gained popularity among Italian humanists and scholars. One example is Epifanio Camicio, an Italian philosopher and rhetorician who lived from 1489 to 1538.

Another significant figure with the name Epifanio was Epifanio de Moirans, a French Catholic missionary and explorer who lived from 1644 to 1689. He played a crucial role in the exploration of the Mississippi River and the establishment of French settlements in the region.

In the 19th century, the name Epifanio was associated with the Italian revolutionary and patriot Epifanio Farina, who lived from 1829 to 1898. He was a prominent figure in the Italian unification movement and fought alongside Giuseppe Garibaldi.

While the name Epifanio has its roots in the Greek language and culture, it has been adopted and used across various regions and time periods, often carrying connotations of divine manifestation, brilliance, and exceptional qualities.