The given name Isabela has its origins in the medieval Occitan and Spanish language forms of Elizabeth, which derived from the Hebrew name Elisheva. The name Elisheva is formed from the components "El" meaning "God" and "shava" meaning "oath" or "fulness". Thus, the name Isabela conveys the meaning "God is my oath" or "Consecrated to God".

The name Isabela became widespread across Europe during the Middle Ages, particularly in Spain and Portugal. One of the earliest known bearers of this name was Isabella I of Castile, also known as Isabella the Catholic, who lived from 1451 to 1504. As Queen of Castile and Aragon, she played a pivotal role in the Spanish Unification and the expulsion of the Moors from the Iberian Peninsula.

In the 13th century, Saint Isabel of France, also known as the Blessed Isabelle of France, was a French princess who embraced a life of poverty and humility as a member of the Order of Franciscan Tertiaries. Her birth and death years were approximately 1225 to 1270.

The name Isabela also appears in the Italian Renaissance period with Isabella d'Este, the Marchioness of Mantua, who lived from 1474 to 1539. She was a prominent figure in the Italian Renaissance, known for her patronage of the arts and her political influence.

Another notable figure was Queen Isabella of Portugal, who lived from 1503 to 1539. As a Princess of Spain and Queen of Portugal, she played a crucial role in the development of the Portuguese Empire and the exploration of the New World.

In the 16th century, Isabella Andreini, an Italian actress and poet, lived from 1562 to 1604. She was renowned for her performances in commedia dell'arte plays and her contributions to Renaissance literature.

The name Isabela has maintained its popularity throughout history and has been borne by numerous notable figures across various cultures and time periods, reflecting its enduring appeal and historical significance.