The name Isidoro has its origins in the Greek language and culture, dating back to ancient times. It is derived from the Greek words "isos" meaning equal and "doron" meaning gift, thus giving it the meaning of "equal gift" or "impartial gift."

In the 6th century, the name gained prominence with Saint Isidore of Seville, a scholar and Archbishop of Seville. He is widely regarded as one of the last scholars of the ancient world and played a crucial role in preserving and transmitting classical knowledge to the Middle Ages. His most notable work, the Etymologiae, was an encyclopedic collection of knowledge covering various subjects.

The name Isidoro has been borne by several notable figures throughout history. One of the earliest recorded examples is Isidore of Miletus, a Greek architect and engineer from the 6th century AD, best known for his work on the Hagia Sophia in Constantinople.

During the Middle Ages, Isidoro became a popular name across Europe, particularly in Spain and Italy. One notable bearer was Isidore the Farmer (c. 1070-1130), a Spanish peasant and farm laborer who is venerated as a saint in the Catholic Church.

In the 16th century, Isidoro Clario (1495-1555) was an Italian Dominican friar and biblical scholar who produced one of the earliest printed translations of the Bible into the Italian language.

Another notable figure was Isidore of Moscow (1438-1474), a Russian monk and icon painter who is considered a pioneer of the Moscow school of icon painting.

In the 19th century, Isidoro Maiztegui (1805-1869) was a prominent Argentine politician and diplomat who served as the Minister of Foreign Affairs and Worship for Argentina.

Throughout its history, the name Isidoro has been borne by individuals from various walks of life, including scholars, religious figures, artists, and politicians, reflecting its enduring presence across different cultures and time periods.