The name Isidra is derived from the Spanish name Isidro, which has its origins in the ancient Greek name Isidoros. The name Isidoros is a combination of two Greek words, "Isis" meaning "gift" and "doron" meaning "gift." The name can be traced back to the ancient Egyptian goddess Isis, who was revered as the ideal mother and wife.

In the early days of Christianity, the name gained popularity due to its association with Saint Isidore of Seville, a 7th-century scholar and Archbishop of Seville. St. Isidore played a crucial role in preserving and transmitting ancient knowledge during the Dark Ages, earning him the title "The Last Scholar of the Ancient World."

The feminine form, Isidra, emerged as a common name among Spanish-speaking communities, particularly in Spain and Latin America. One of the earliest recorded instances of the name Isidra can be found in the 13th-century Spanish epic poem "Cantar de Mio Cid," where it is mentioned as the name of a character.

Throughout history, several notable figures have borne the name Isidra. One of the most famous was Isidra Guzmán y de la Sentísima Trinidad (1805-1856), a Dominican Catholic nun and mystic from Ecuador. She is revered as a folk saint and is known for her visions and miraculous healings.

Another notable Isidra was Isidra Quesada (1789-1854), a Cuban revolutionary who played a significant role in the struggle for Cuban independence from Spanish colonial rule. She is remembered as a symbol of patriotism and bravery in Cuban history.

In the realm of literature, Isidra Aguirre (1919-2011) was a renowned Mexican writer and poet. She is celebrated for her contributions to contemporary Mexican literature and her exploration of feminist themes.

The name Isidra also has historical connections to the Philippines. Isidra Reyes (1899-1990) was a Filipino teacher and activist who fought for women's rights and social justice. She founded the Philippine Columbian Association, one of the earliest women's organizations in the country.

Finally, Isidra Castellví i Caralt (1848-1944) was a Spanish educator and feminist pioneer from Catalonia. She was a prominent figure in the women's rights movement and worked tirelessly to promote female education and empowerment in Spain.