The name Isis has its origins in ancient Egyptian mythology and language. It is derived from the Egyptian word "Ese", meaning "throne" or "seat". Isis was one of the most significant deities in the ancient Egyptian pantheon, revered as the ideal wife and mother, as well as the goddess of fertility, healing, and magic.

The earliest recorded instances of the name Isis can be traced back to the Old Kingdom of Egypt, around 2686-2181 BC. The name appears frequently in ancient Egyptian texts, including the Pyramid Texts and the Book of the Dead, which were funerary texts inscribed on the walls of ancient Egyptian tombs and pyramids.

One of the most famous historical figures with the name Isis was the ancient Egyptian queen, Isis the Great, who ruled as the fifth ruler of the 26th Dynasty of Egypt from 690-685 BC. She was the daughter of Psamtik I and is known for her efforts in restoring Egyptian traditions and customs.

In Greek mythology, Isis was associated with the goddess Demeter, and her worship spread throughout the Greco-Roman world. The name appears in various ancient Greek and Roman texts, including the writings of Plutarch, Diodorus Siculus, and Apuleius.

During the Renaissance period, the name Isis was revived by humanists and scholars who were fascinated by ancient Egyptian culture. One notable figure was Isis Nogarola (1420-1466), an Italian Renaissance humanist and one of the first women to deliver public orations.

Another historical figure named Isis was Isis Unveiled (1831-1891), the famous Russian occultist and author, whose real name was Helena Petrovna Blavatsky. She founded the Theosophical Society and wrote the influential book "Isis Unveiled" in 1877, which explored ancient and esoteric wisdom.

In more recent times, the name Isis has been used by a few notable individuals, such as Isis Gee (born 1987), a British actress and model, and Isis King (born 1985), an American actress and model who was the first transgender contestant on America's Next Top Model.