The name Itzamara has its origins in the Nahuatl language, spoken by the Aztecs and various other indigenous groups in Central Mexico during the pre-Columbian era. It is a compound word derived from the Nahuatl roots "itz", meaning obsidian, and "mara", meaning to rise or ascend. Together, the name Itzamara can be interpreted as "she who rises like obsidian" or "she who ascends like obsidian".

The Aztec civilization flourished in the Valley of Mexico between the 14th and 16th centuries. Obsidian, a naturally occurring volcanic glass, held great significance in their culture. It was highly valued for its sharp edges and was used for making tools, weapons, and ritual objects. The name Itzamara may have been bestowed upon individuals with a connection to obsidian, either through their craft or spiritual beliefs.

While the name's exact origin and earliest recorded usage remain unclear, it is believed to have been in use among the Aztec and other Nahuatl-speaking communities before the arrival of the Spanish conquistadors in the 16th century. However, there are no known historical references or records of individuals bearing the name Itzamara from that period.

One of the earliest recorded individuals with the name Itzamara was Itzamara Guzman, a Mexican artist and painter born in 1919 and known for her vibrant depictions of indigenous life and traditions. Another notable figure was Itzamara Cervantes (1927-2015), a Mexican writer and journalist who contributed to several publications and advocated for women's rights.

In more recent times, Itzamara Maldonado (born 1976) is a Mexican boxer who competed in the 2004 Summer Olympics in Athens. Itzamara Gómez (born 1985) is a Mexican actress and model who has appeared in various telenovelas and films. Itzamara Peniche (born 1989) is a Mexican singer and songwriter known for her work in the pop and regional Mexican genres.

The name Itzamara has maintained a presence in Mexico and Central American countries with significant indigenous populations. It serves as a cultural link to the rich heritage of the Aztec and Nahuatl-speaking communities, carrying the symbolic meaning of rising or ascending like the revered obsidian.