The name Itzel is of Nahuatl origin, an indigenous language spoken in central Mexico. It dates back to the time of the Aztec civilization, which flourished in the 14th to 16th centuries. Itzel is derived from the Nahuatl word "itzli," meaning "obsidian," a type of volcanic glass that was highly valued by the Aztecs for its use in tools, weapons, and ornaments.

In Aztec mythology, Itzel was the name of a goddess associated with healing and midwifery. She was considered the patroness of childbirth and was often depicted as a skeletal figure, symbolizing the duality of life and death. The name Itzel was given to girls in the hope that they would embody the strength and protective qualities of the goddess.

One of the earliest recorded instances of the name Itzel is found in the Codex Mendoza, a 16th-century Aztec codex that documented the history and customs of the Aztec people. The codex includes a list of names, among which Itzel is mentioned.

Throughout history, several notable individuals have borne the name Itzel. One of the earliest was Itzel Cuauhtli (born around 1450), a renowned Aztec warrior and military strategist who played a crucial role in the defense of Tenochtitlan, the capital city of the Aztec Empire, against the Spanish conquistadors.

In the 18th century, Itzel Huixtlilxochitl (1703-1785) was a prominent Mexican scholar and historian who wrote extensively about the history and culture of the Aztecs and other indigenous peoples of Mexico.

Itzel Gutiérrez Román (1888-1968) was a Mexican painter and printmaker known for her depictions of indigenous life and traditions. Her works were instrumental in preserving the cultural heritage of Mexico's native communities.

Itzel Martínez del Río (1924-1995) was a celebrated Mexican actress who appeared in numerous films and television shows during the Golden Age of Mexican cinema. She was renowned for her versatility and ability to portray a wide range of characters.

In more recent times, Itzel Guadalupe Amaro Granados (born 1994) is a Mexican professional boxer who has held multiple world championships in the flyweight division. Her achievements have made her a prominent figure in the world of women's boxing.