The given name Jaymie is a modern English variant of the classic name James, which traces its roots back to the Late Latin name Iacomus, itself derived from the Hebrew name Ya'aqov. The name Ya'aqov means "supplanter" or "one who follows" in Hebrew, a reference to the Biblical patriarch Jacob's birth story.

The name James gained widespread popularity throughout Europe during the Middle Ages, particularly due to its association with two prominent figures in early Christianity - Saint James the Great, one of the Twelve Apostles, and Saint James the Lesser, an apostle and the first bishop of Jerusalem. As a result, the name James became a favored choice among Christians across the continent.

One of the earliest recorded bearers of the name James was James the Just, also known as James the Brother of the Lord, who lived in the 1st century AD and is revered as a significant figure in the early Christian church. Another notable James from antiquity was James the Persian, a 4th-century Christian martyr who was executed for his faith in Persia (modern-day Iran).

During the Middle Ages, the name James gained particular prominence in England, with several English kings bearing the name, including James I (1566-1625), who oversaw the translation of the King James Bible, and James II (1633-1701), the last Catholic monarch to reign over England, Scotland, and Ireland.

Other notable historical figures named James include the Scottish philosopher James Mill (1773-1836), the American novelist Henry James (1843-1916), and the Irish novelist and poet James Joyce (1882-1941).

While the spelling "Jaymie" is a more recent variation, it reflects the modern trend of creating unique or personalized spellings of traditional names, often by altering the vowel sounds or adding additional letters. This trend has become increasingly popular in recent decades, though the origins and meanings of these modified spellings are rooted in the rich historical and cultural significance of the original name.