The name Jerone is a variant spelling of the name Jerome, which has its origins in the late Roman era. It derives from the Greek name Hieronymus, which was formed from the elements hieros, meaning "sacred," and onyma, meaning "name." This combination suggests the meaning "sacred name" or "holy name."

The name Jerone was particularly popular during the Middle Ages, when it was borne by several notable figures in the Christian church. One of the most famous was St. Jerome, a 4th-century scholar and priest who is best known for his translation of the Bible into Latin, known as the Vulgate. He was born around 347 AD in Stridon, a town on the border of Dalmatia and Pannonia (modern-day Croatia and Hungary).

Another notable bearer of the name was Jerome of Prague, a 15th-century Czech philosopher, reformer, and one of the principal followers of Jan Hus. He was born around 1379 and was burned at the stake as a heretic in 1416.

In the 16th century, Jeronimo Münzer, a Spanish traveler and writer, was known for his detailed accounts of his travels throughout Europe and the Middle East. He was born in Valencia, Spain, around 1460.

During the Italian Renaissance, the name was also borne by the painter Girolamo Genga, who was born in Urbino, Italy, around 1476. He is best known for his work on the Palazzo del Te in Mantua.

In the 17th century, Jerónimo de Ayanz y Beaumont was a Spanish inventor and military engineer who is credited with developing one of the first steam-powered devices. He was born in Navarre, Spain, around 1590.

While the name Jerone has its roots in ancient Greek and Latin, it has been used across various cultures and regions throughout history, reflecting the widespread influence of the Christian faith and its notable figures.