The name Mikyle is a variant spelling of the English name Michael, which has its origins in the Hebrew name Mikhael. Mikhael is derived from the Hebrew words "mi" meaning "who" and "ka" meaning "like," combined with "El" which is one of the Hebrew words for God. Thus, the name Mikhael means "Who is like God?"

The name Mikhael appears in the Bible, referring to the archangel Michael who is depicted as the leader of the angels and the protector of the people of Israel. The name was adopted by early Christians and spread throughout Europe with different spellings such as Michael, Michel, Miguel, and Michal.

The variant spelling Mikyle emerged in the late Middle Ages, likely as a result of regional dialects and the influence of other languages. One of the earliest recorded instances of this spelling can be found in the 15th century English poem "The Crede of Piers Plowman," where the name is spelled as "Mykyle."

Over the centuries, several notable figures have borne the name Mikyle or its variants. One of the earliest was Mikyle Skulitz, a Czech theologian and reformer born around 1395, who was a follower of Jan Hus and a proponent of the Hussite movement.

In the 16th century, Mikyle de la Pole was an English soldier and nobleman who fought in the Wars of the Roses and was executed in 1517 for his role in the Lincolnshire Uprising against King Henry VIII.

During the 17th century, Mikyle van Beverhovick was a Dutch physician and writer who published works on various medical topics, including a treatise on the preservation of health in 1636.

In the 18th century, Mikyle Laski was a Polish nobleman and military commander who served in the Polish Army during the reign of King Stanislaw II Augustus and participated in the Polish-Russian War of 1792.

Finally, in the 19th century, Mikyle Obrenovich was a Serbian prince and member of the House of Obrenović, who briefly served as the regent of Serbia from 1868 to 1872 during the minority of his nephew, King Milan I.