The name Missy is a diminutive form of the name Melissa, which has its roots in Greek mythology. Melissa was a nymph who nurtured the infant Zeus with honey, and her name derives from the Greek word "melissa," meaning "honeybee." The name entered the English language through the Latin "Melissa," and its popularity peaked in the United States during the late 20th century.

Historically, the name Missy was primarily used as a nickname or pet name for women named Melissa. However, it eventually gained recognition as a given name in its own right. One of the earliest recorded instances of Missy as a first name dates back to the 19th century, when American author Harriet Beecher Stowe introduced a character named Missy in her novel "Dred: A Tale of the Great Dismal Swamp" published in 1856.

In ancient Greek mythology, the figure of Melissa, the honey-nymph, was celebrated for her nurturing and sweet nature. The association with honey and bees lent the name a positive connotation, symbolizing industriousness, fertility, and sweetness of character. This mythological connection may have contributed to the enduring appeal of the name and its variations.

Throughout history, several notable individuals have borne the name Missy. One of the earliest examples is Missy LeHand (1892-1953), an American politician who served as the private secretary to President Franklin D. Roosevelt. Other prominent figures include Missy Elliott (born 1971), an American rapper, singer, and producer; Missy Giove (born 1969), an American former professional tennis player; and Missy Franklin (born 1995), an American former competitive swimmer and six-time Olympic gold medalist.

Additionally, the name Missy has been featured in various literary works and pop culture references. In the novel "Gone with the Wind" by Margaret Mitchell, one of the characters is named Missy, and the name has also been used for characters in television shows and films, further contributing to its familiarity and recognition.