The given name Rojelio originated from the Spanish and Latin American cultures, with its roots tracing back to ancient Rome. It is believed to be a variant of the name Rogelio, which derives from the Latin name Rogerius. In turn, Rogerius is thought to have originated from the Germanic name Hrodger, which consists of the elements "hrod" (fame) and "ger" (spear).

The earliest known record of the name Rojelio can be found in Spanish and Latin American historical documents dating back to the 16th century. During this period, the name was primarily used by individuals of Spanish or Latin American descent, often within the context of the Catholic faith.

One of the earliest known individuals bearing the name Rojelio was Rojelio Martínez, a Spanish conquistador who participated in the conquest of the Aztec Empire in the early 16th century. Another notable figure from this era was Rojelio de Alvarado, a Spanish Catholic missionary who played a significant role in the evangelization efforts in the Americas.

In the 17th century, the name Rojelio gained prominence among the Spanish nobility and upper-class families. One such individual was Rojelio de Mendoza (1630-1702), a Spanish nobleman and military officer who served in the Spanish army during the Thirty Years' War.

As the centuries progressed, the name Rojelio continued to be used across the Spanish-speaking world, with notable individuals emerging in various fields. For example, Rojelio Naranjo (1820-1890) was a renowned Ecuadorian poet and writer, while Rojelio Hernández (1905-1988) was a celebrated Mexican painter known for his vibrant depictions of rural life.

In the 20th century, the name Rojelio gained further recognition through the accomplishments of individuals like Rojelio García (1915-2002), a Cuban-American artist and sculptor whose works explored themes of identity and cultural heritage. Additionally, Rojelio Rodríguez (1932-2018) was a respected Mexican actor and comedian who entertained audiences with his comedic performances on stage and television.

While the name Rojelio has its roots in Spanish and Latin American cultures, it has also been adopted and used in other parts of the world, particularly among communities with strong Hispanic ties or influences. However, its historical significance and cultural relevance remain deeply rooted in the rich traditions of the Spanish-speaking world.