The given name Siouxsie is a relatively modern invention, emerging in the late 20th century. It is a creative combination of the words "Sioux," referring to the Native American tribe, and the English diminutive suffix "-sie." This unique blend of elements was likely crafted as a distinctive moniker with a nod to indigenous American culture.

While the Sioux people have a rich linguistic tradition, the name Siouxsie itself does not seem to have direct origins in their language or nomenclature. Its emergence can be traced back to the rise of the punk and new wave music scenes in the late 1970s and early 1980s.

One of the earliest and most notable bearers of the name was Siouxsie Sioux, the stage name of Susan Ballion, the lead singer of the influential British punk rock band Siouxsie and the Banshees. Born in 1957, Siouxsie Sioux was a pioneering figure in the punk and goth subcultures, known for her distinctive vocals and striking visual style.

Beyond the music world, a few other notable individuals have carried the name Siouxsie. Siouxsie Cooper, born in 1969, is an American model and actress who has appeared in various films and television shows.

Siouxsie Wiles, born in 1977, is a British-born microbiologist and science communicator based in New Zealand, known for her work in promoting public understanding of science during the COVID-19 pandemic.

Siouxsie Cooper, born in 1990, is an American singer-songwriter and actress who has appeared in several television series and films.

Siouxsie Gillett, born in 1992, is a British model and actress who has graced the covers of various fashion magazines and appeared in several music videos.

While the name Siouxsie is a modern creation, its unique combination of elements has captured the imagination of various individuals, allowing them to express their individuality and, in some cases, pay homage to indigenous American culture through their chosen moniker.