The name Stefanie has its origins in the Greek language and culture. It is derived from the Greek word "stephanos," which means "crown" or "wreath." The name's earliest recorded use dates back to ancient Greece, where it was given as a name to honor the goddess Stephania, a minor deity associated with crowns and wreaths.

In the early Christian era, the name gained popularity as a variant of the name Stephanos, which was borne by several early Christian martyrs and saints. One of the most notable was Saint Stephen, the first Christian martyr, who was stoned to death in Jerusalem around 33 AD. His name, derived from the same Greek root, contributed to the widespread use of Stefanie and its variations throughout Christian communities.

During the Middle Ages, the name spread across Europe, particularly in regions with strong Greek or Byzantine cultural influences. It was frequently given to children in honor of Saint Stephen, and variations like Stephanie and Stefania emerged in different languages and cultures.

One of the earliest recorded instances of the name Stefanie can be found in the 12th century, when it was used by the Byzantine princess Stefanie, daughter of the Emperor Manuel I Comnenus. Another notable figure was Stefanie von Hohenzollern, a 13th-century German noblewoman and the wife of Duke Rudolf IV of Austria.

Throughout history, several prominent figures have borne the name Stefanie. These include Stefanie Quintini (1600-1663), an Italian painter and poet during the Baroque period; Stefanie Felicita, Duchess of Milan (1637-1704), a German princess and regent; and Stefanie de Loperato (1720-1769), an Italian composer and harpsichordist.

In the 19th century, Stefanie Herzogin von Württemberg (1837-1917) was a German aristocrat and the wife of King Ferdinand I of Romania. Another notable figure was Stefanie Gräfin von Belgioioso (1819-1894), an Italian writer, philosopher, and activist.

During the 20th century, Stefanie Maria Elisabeth Herzogin von Brabant (1864-1945) was a notable Austrian archduchess and the mother of Emperor Charles I of Austria. Additionally, Stefanie Powers (born 1942) is an American actress known for her roles in television series like "Hart to Hart."